pancreatic protective and hypoglycemic effects of vitex agnus-castus l. fruit hydroalcoholic extract in d-galactose-induced aging mouse model

Authors

akram ahangarpour 1health research institute, diabetes research center, department of physiology, ahvaz jundishapur university of medical sciences, ahvaz, i.r. iran.

ali akbar oroojan 2department of physiology, student research committee of ahvaz jundishapur university of medical science, ahvaz, i.r. iran.

layasadat khorsandi 3cell and molecular research center, department of anatomical sciences, faculty of medicine, ahvaz jundishapur university of medical sciences, ahvaz, i.r. iran.

seyedeh asma najimi 4physiology research center, department of physiology, ahvaz jundishapur university of medical sciences, ahvaz, i.r. iran.

abstract

d-galactose induces pancreatic disorder along with aging mouse model. vitex agnus-castus (vac) has potential pancreatic protective effect. hence, this study was designed to evaluate the hypoglycemic and pancreas protective effects of vac hydroalcoholic extract in d-galactose-induced aging female mice. in the present experimental study, 72 adult female naval medical research institute (nmri) mice (weighing 30–35 g) were divided into 6 groups of control, vac hydroalcoholic extract, d-galactose, d-galactose + vac hydroalcoholic extract, aged, aged + vac hydroalcoholic extract. the aged model was prepared by subcutaneous injection of d-galactose for 45 days and, vac hydroalcoholic extract was gavaged twice a day in the last 7 days. 24 h after the last drug and extract administrations, serum samples and pancreatic tissues were removed to evaluate experimental and histological determinations. serum glucose level decreased in vac, d-galactose and, aged-treated groups compared to the control ( p < 0.05). insulin level increased in vac and decreased in d-galactose and aged vac-treated mice compared to the control ( p < 0.05). homeostasis model assessment-estimated insulin resistance (homa-ir) increased in d-galactose, aging, and vac hydroalcoholic extract groups ( p < 0.05) and, administration of vac hydroalcoholic extract improved homa-ir in d-galactose and aging treated animals. despite the size of pancreatic islets decreased in aged and d-galactose groups, vac administration recovered it. present data showed that vac hydroalcoholic extract has hypoglycemic and pancreatic protective effects in natural aged and aging                   model mice.

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Journal title:
research in pharmaceutical sciences

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